We find ourselves watching John's average weekend.
Panel 1: We find ourselves at John's clinic; as he puts X-rays into a filing cabinet, Jean says "Good night, Doctor P!". He wishes her a good night and a good weekend as well.
Panel 2: He then thought-bubbles "Whoa! What a week!"
Panel 3: As he locks up, he smiles and thought-bubbles "Ahhhh!! Friday!"
Panel 4: He practically skips down the hallyway as he thought-bubbles "I can escape the office for two days!"
Panel 5: On the drive home, he thought-bubbles "No patients, no staff, no business troubles!"
Panel 6: We start to see the error in his logic as soon as he gets in the door; that's because Mike and Lizzie are angrily fighting over a stuffed toy.
Panel 7: We remind ourselves that Elly is too stupid to make sure that Farley is walked and fed properly because she yells at him while cleaning up his mess.
Panel 8: She then yells at John because he tracked a bit of mud in the house so he could oppress her by adding work to her busy life.
Panel 9: As the children yell about the stuffed toy and Elly makes that stupid palms-out gesture as she yet again lectures him about how hard it is to be a busy mother with nooooo help and noooo time to herself, John is staggered because he has to read the Honey-Do List From Hell; given that he pretty much has to keep the house from collapsing in on itself, he can pretty much kiss his quiet weekend good-bye.
Panel 10: We next see him opening up the clinic for the week thought-bubbling "Ahhhh! MONDAY!!!!"
Summary: The problem, of course, is that this cycle is self-sustaining; by the time Friday rolls around, he imagines that his family is an oasis of calm and stability after a week of dull, thankless, draining work all over again only to imagine that work is a haven from domestic unpleasantness on Monday. Eventually, he takes up toy trains.