Panel 2: Ooooooh, that looks like a VERY ominous road. You know, both my mom and my husband have driven so long at a stretch that they've ended up hallucinating, and (mom) slowing down to appease cops that weren't there and (Cookie Monster) stopping to let pedestrians cross who weren't there. (Having learned by example, I NEVER push myself that hard. (And those were two separate journeys.))
Panel 3: Well, even stopping and sleeping in the car for a bit is good.
Panel 4: But maybe not when you're alone...
It's hard to say. On the one hand, if you're too tired to drive, STOP. On the other, some places aren't safe to stop. Ordinarily, I'd say Elly should forgo her need to be fawned over in favor of her need to rest. But in this case, she could be a target for Howard's cousin...
At any rate, this. Had better. Be going. Somewhere.