Panel 1: We start off with Ted taking John to what dim suburbanites like them think an English pub is like. It's probably just me but I think calling the place the Swig and Swine is far too obvious.
Panel 2: John's toast "Well, here we are --- to us" sounds eerily like the Best Friends Forever nonsense that the bridesmaids spouted during the Settlepocalypse. Ted's response of "To life, liberty and the pursuit of happiness" is hardly better.
Panel 3: As a waitress, who looks like a teenaged Meredith, catches his attention, Ted says that he's found some happiness he'd like to pursue.
Panel 4: She asks him if she can get them something else. Ted tells her "Sure -- you're something else."
Panel 5: Instead of asking if his friend is having a stroke, having just made no sense and all, John barks "tone it down, man!" Ted continues to spout Phil-Ken-Sebben like gibberish by promising to do so after he's done cranking it up.
Summary: We might actually be in for an Aesop about how John should be grateful that he doesn't need to worry about pursuing happiness, it being both irrelevant and overrated.