Panel 1: We come across Miss Edwards asking Liz what's wrong. Liz makes the mistake of telling her that she's depressed.
Panel 2: This is because a woman who knows nothing of Liz's domestic situation tells her that crazy puberty hormones are to blame for things. This is at least consistent because when Liz finally talks about the massive flapping anus that is Mike, she gets his motivation wrong too.
Panel 3: When Liz wonders if she's turning into the raging vortex of mother-hating insanity that is a teenager, Edwards says yes.
Panel 4: She then tells her not to do it in her class.
Summary: This is the same sort of stupid "Why the HELL would you say that? Are you some kind of imbecile?" anti-advice Elly is great at dispensing.