Panel 2: Jeeeeeeez! Not only a yam schnozz, but a Jay Leno jaw! And I don't recall her adjusting; I remember her repeatedly moaning and groaning and being reassured (or ribbed) by John.
Panel 3: Actually, she had lines around her mouth even earlier than that. I recall elem-school-aged Mike telling her she had a smile "with brackets", which did evoke a genuine smile. And again, she wasn't happy with her looks in her '40s, either.
Panel 4: Echhhh! Wattle!
Panel 5: Oh. Brother. This is going up on SO many fridges. Yam nose and all.